Research Compendium/NAD⁺
Anti-Ageing & LongevityResearch OnlyNot For Human Consumption

NAD⁺

Nicotinamide Adenine Dinucleotide · NAD+ injectable

The molecule that powers every cell, levels halve every decade, and injectable NAD⁺ tops them back up faster than any pill can.

MECHANISM OF ACTION

NAD⁺ is a molecule found in every single cell in your body. It acts like a rechargeable battery, it picks up energy from food and delivers it to the cell's power plants (mitochondria). Beyond energy, it also feeds the proteins responsible for repairing damaged DNA and those linked to living longer (called sirtuins). The catch: your NAD⁺ levels drop roughly 50% for every decade of life after your 20s. This is linked to slower energy, reduced DNA repair, and general ageing effects. Oral supplements like NMN or NR are converted into NAD⁺ by the body, a slower process. Injectable NAD⁺ bypasses that conversion and raises levels in the bloodstream directly and fast.

RESEARCH APPLICATIONS

  • Mitochondrial bioenergetics restoration
  • Sirtuin activation (SIRT1/3 longevity pathway)
  • DNA repair enhancement (PARP substrate)
  • Cellular energy metabolism and mitochondrial function research
  • Cognitive clarity and neurological function research

RESEARCH HIGHLIGHTS

Sirtuin Activation and Longevity

2013

NAD⁺ repletion in aged preclinical subjects activated SIRT1 and SIRT3, restoring mitochondrial function, improving muscle endurance, and extending healthspan in multiple studies.

Ref: Gomes et al., Cell

DNA Repair via PARP

2016

NAD⁺ depletion impairs PARP-mediated DNA repair; repletion restores repair capacity - particularly relevant in age-related genomic instability models.

Ref: Fang et al., Cell Metabolism

RESEARCH PROTOCOL NOTES

Injectable formats300–1000mg IV infusion or SC injection
IV noteIV infusion causes flush/tightness at rapid rates - slow infusion over 2–3 hours recommended
Available formatsVial (300–600mg), Pen (1000mg - NAD+ Pen)
vs. NMN/NRInjectable NAD+ achieves faster repletion; NMN/NR are oral precursors converted to NAD+ intracellularly

Chemical Identity

Molecular FormulaC21H27N7O14P2
Molecular Weight663.4 g/mol
CAS Number53-84-9
SolubilityHighly soluble in water

Storage & Stability

Lyophilised: 2–8°C, 12–24 months. Reconstituted: use within 24–48 hours at 2–8°C. Highly sensitive to light and oxidation - use amber vials, protect from air.

Regulatory Status

Not a registered pharmaceutical. Injectable vials supplied as research compound only. Not WADA prohibited.

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