MECHANISM OF ACTION
MOTS-C is unusual: most peptides are made from your main DNA, but this one is encoded in the DNA inside your mitochondria (the tiny power plants inside every cell). It's one of the first peptides discovered to be made this way and then travel through the body like a hormone. It activates a molecule called AMPK, a master switch that senses low energy and responds to exercise. When AMPK switches on, the body studied for fat metabolism more efficiently, becomes more sensitive to insulin (so blood sugar is better controlled), and produces more energy. Research in aged animals showed MOTS-C restored physical performance to levels seen in younger subjects. Its levels naturally decline with age, which is why it is studied in research on metabolic signalling.
RESEARCH APPLICATIONS
- AMPK activation research
- Mitochondrial signalling studies
- Metabolic flexibility research models
- Age-related metabolic signalling
RESEARCH HIGHLIGHTS
Mitochondrial-derived signalling
2015Research describes it as one of a small group of peptides encoded by mitochondrial DNA, which is why it is studied as a distinct signalling class. Research observations only.
Ref: Lee et al., Cell Metab
RESEARCH PROTOCOL NOTES
Chemical Identity
Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Storage & Stability
Lyophilised: -20°C. Reconstituted: 2–8°C, 14–21 days. Relatively fragile - handle gently, avoid vortexing.
Regulatory Status
Unscheduled in South Africa. Supplied for laboratory and research use only. Not a registered medicine, not evaluated by SAHPRA, not for human consumption. Not currently WADA prohibited.
Important - read before proceeding
This page is a summary of published scientific literature about a molecule. It is provided for research and educational purposes only. Nothing on this page is medical advice, a diagnosis, a recommendation, a prescription, or a claim that this compound treats, cures, prevents or improves any condition in humans. Research findings described here are observations reported by third-party researchers about the molecule - they are not statements about the product supplied by Bio Intelligence, and they should not be read as an expected outcome.
Compounds supplied are not registered medicines, have not been evaluated by SAHPRA, and are not for human consumption. No dosing, route of administration or usage guidance is provided by Bio Intelligence. If you have a health concern, speak to a registered healthcare practitioner.