Research Compendium/MOTS-C
Anti-Ageing & LongevityResearch OnlyNot For Human Consumption

MOTS-C

Mitochondrial Open Reading Frame Twelve Peptide C · Mito Boost peptide

A peptide made inside your mitochondria, it acts like an exercise signal, improving metabolism and energy even in aged research subjects.

MECHANISM OF ACTION

MOTS-C is unusual: most peptides are made from your main DNA, but this one is encoded in the DNA inside your mitochondria (the tiny power plants inside every cell). It's one of the first peptides discovered to be made this way and then travel through the body like a hormone. It activates a molecule called AMPK, a master switch that senses low energy and responds to exercise. When AMPK switches on, the body studied for fat metabolism more efficiently, becomes more sensitive to insulin (so blood sugar is better controlled), and produces more energy. Research in aged animals showed MOTS-C restored physical performance to levels seen in younger subjects. Its levels naturally decline with age and obesity, which is why it's studied for longevity and metabolic health.

RESEARCH APPLICATIONS

  • AMPK activation and metabolic flexibility research
  • Exercise-mimetic modelling (physical performance without exercise)
  • Insulin sensitivity and T2D models
  • Longevity and age-related metabolic decline
  • Shredded stack - adipose research via metabolic rate modulation

RESEARCH HIGHLIGHTS

Exercise Mimetic Effect

2021

MOTS-C injections in preclinical ageing models restored exercise capacity, muscle function, and metabolic flexibility to levels comparable to younger subjects.

Ref: Reynolds et al., Nature Aging

AMPK-Mediated Insulin Sensitisation

2015

MOTS-C administration reversed high-fat diet-induced insulin resistance in preclinical models via AMPK/GLUT4 pathway upregulation.

Ref: Lee et al., Cell Metabolism

RESEARCH PROTOCOL NOTES

Research doses5–10 mg SC ; human research doses emerging
Available formatsVial (20–60mg), Pen (Mito Boost 60mg - Peptide Pen), Pen (MOTS-C 32mg - BodyPharm)
Stack contextComponent of Shredded stack (with AOD-9604, Tesamorelin)

Chemical Identity

Molecular FormulaC101H180N34O30S
Molecular Weight2174.8 g/mol
CAS Number1448695-81-5
SolubilitySoluble in water

Sequence

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Storage & Stability

Lyophilised: -20°C. Reconstituted: 2–8°C, 14–21 days. Relatively fragile - handle gently, avoid vortexing.

Regulatory Status

Research compound. No regulatory approval. Not currently WADA prohibited. SAHPRA: unscheduled.

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