Research Compendium/DSIP
Brain & NootropicsResearch OnlyNot For Human Consumption

DSIP

Delta Sleep-Inducing Peptide · DSIP nonapeptide

A natural brain peptide that studied in connection with deeper, more restorative sleep and helps the body manage stress, without the addiction risk of sleep drugs.

MECHANISM OF ACTION

DSIP (Delta Sleep-Inducing Peptide) was discovered in the 1970s when researchers found it in the blood of sleeping animals. When injected into awake animals, it triggered the deep, slow-wave sleep stage (delta sleep), the most restorative phase. It works by gently enhancing the brain's calming GABA system and activating opioid receptors, similar pathways to sleep drugs, but without causing dependence. It also dials down the stress hormone system, studied for effects on cortisol (the "fight or flight" hormone) after stressful events. It's been used in Russian clinical settings for stress-related conditions and withdrawal from certain substances.

RESEARCH APPLICATIONS

  • Sleep quality and delta-wave architecture research
  • HPA axis stress response modulation
  • Opioid withdrawal and substance dependence models
  • Neuroprotection and anti-apoptotic models
  • Circadian rhythm and neuroendocrine research

RESEARCH HIGHLIGHTS

Original Delta Sleep Induction

1977

First characterised as the active component in cerebral venous blood of sleeping preclinical subjects - intraventricular injection produced reproducible delta sleep pattern in recipient preclinical subjects.

Ref: Monnier et al., Pflügers Arch

HPA Axis Attenuation

1986

DSIP administration reduced ACTH and corticosterone response to restraint stress , proposing a role in HPA axis buffering.

Ref: Graf & Kastin, Neurosci Biobehav Rev

RESEARCH PROTOCOL NOTES

Research doses0.5–1 mg SC in human studies
TimingPre-sleep administration in sleep research protocols
Available formatsVial (lyophilised)

Chemical Identity

Molecular FormulaC35H48N10O15
Molecular Weight848.8 g/mol
CAS Number62568-57-4
SolubilitySoluble in water

Sequence

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Storage & Stability

Lyophilised: -20°C. Reconstituted: 2–8°C, 14 days. Relatively unstable in solution - use promptly.

Regulatory Status

Used in Russian practice for stress/withdrawal (not formally registered as drug). No FDA/EMA approval. Research compound. Not WADA prohibited.

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