MECHANISM OF ACTION
BPC-157 is a small chain of 15 building blocks (amino acids) originally found in the stomach's protective lining. Research shows it helps grow new blood vessels in injured areas, improves blood flow, and kick-starts the repair process in damaged cells. It is also studied for its role in managing inflammation signalling. Studies have looked at tendon injuries, ligament tears, gut damage, bone fractures, and even brain protection. It's one of the most well-researched peptides in the recovery space.
RESEARCH APPLICATIONS
- Tendon and ligament recovery (Achilles, rotator cuff, MCL models)
- Gastrointestinal mucosal protection and fistula models
- Angiogenesis and wound-closure research
- CNS protection models (TBI, inflammatory bowel disease)
- Bone fracture repair and cartilage regeneration
RESEARCH HIGHLIGHTS
Tendon-to-Bone Healing Acceleration
2018Multiple preclinical studies demonstrate significant acceleration of Achilles tendon recovery vs. controls, with histological evidence of improved collagen organisation at 14 and 28 days.
Ref: Sikiric et al., J Physiol Pharmacol
GI Mucosal Cytoprotection
2009BPC-157 showed protective effects against NSAID-induced gastric ulceration , with proposed mechanism via NO pathway modulation.
Ref: Ilic et al., World J Gastroenterol
Angiogenic Activity via VEGFR2
2005In vitro and in vivo data confirm upregulation of VEGFR2, with consequent endothelial proliferation and capillary formation - relevant for wound-bed vascularisation.
Ref: Hsieh et al., Regul Pept
RESEARCH PROTOCOL NOTES
Chemical Identity
Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Storage & Stability
Lyophilised: -20°C, protected from light. Reconstituted: use within 28 days at 2–8°C. Avoid repeated freeze-thaw cycles.
Regulatory Status
No FDA, EMA, or SAHPRA approval for human use. Research compound. WADA: not explicitly prohibited as of 2024.